Full instructions, dosage information and potential known side effects are all available in the leaflet that comes with the prescription product. If you require any advice or assistance with placing your order, please donâ€™t hesitate to contact our team.
How do I take/use this medicine?
Take Clozapine exactly as directed by your doctor. Do not take more or less than instructed by your doctor.
Clozapine is available as a conventional tablet and as an oral disintegrating tablet.
If you have been given the conventional tablet, swallow it with a glass of water.
If you have been given the oral disintegrating tablet, remove it from the foil only just before you take it. Place the tablet on your tongue and allow it to dissolve. Then, swallow it with your saliva. If you are taking only part of the tablet, throw away the part that is not taken.
Clozapine may be taken with or without food. Try to take it at the same time everyday.
Do not stop taking Clozapine unless instructed by your doctor. You may feel unwell if Clozapine is stopped suddenly. When your doctor decides that you do not need Clozapine anymore, he will usually reduce your dose slowly. Follow the doctor's instructions carefully.
Do not switch between different brands of Clozapine unless your doctor has told you to do so.
What should I take note of while using/taking this medicine?
Alert your doctor if you are pregnant or if you become pregnant while being treated with Clozapine. Use effective birth control methods while being treated with Clozapine.
Do not breastfeed while you are being treated with Clozapine. Alert your doctor if you are breastfeeding.
Clozapine may cause your white blood cell count to drop drastically. This may put you at higher risk for infections. For as long as you are being treated with Clozapine, you will need to have regular blood tests done. These blood tests are very important for you. These tests help your doctor to check that your white blood cell counts are within the normal range. Your doctor will advise you about how often you need to have these blood tests. Be very sure to keep all appointments with your doctor.
Alert your doctor if you have any of these conditions:
- a tendency to develop blood clots or if you ever had blood clots in the leg (deep vein thrombosis or DVT) or lung (pulmonary embolism or PE)
- previous abdominal surgery
- prostate problems or difficulty passing urine
- eyesight problems such as glaucoma (increased pressure in the eye)
- myasthenia gravis (a condition that causes muscle weakness)
Inform your doctor if you have diabetes. Clozapine may cause your blood sugar levels to rise. Monitor your blood sugar levels more regularly if you have diabetes or a family history of diabetes.
If you are going for an operation, including minor operations and dental work, inform your doctor or dentist that you are being treated with Clozapine.
When should I not use this medicine?
Alert your doctor if you have any of these conditions. Clozapine may or may not be suitable for you if you have any of these conditions.
- bone marrow disease
- low white blood cell count
- epilepsy (fits)
- bowel blockage or bowel paralysis (paralytic ileus) which causes severe constipation
- other bowel diseases
- heart, liver or kidney disease
- mental illness caused by alcohol or drug addiction
Alert your doctor if you have taken Clozapine in the past and let him know if Clozapine has ever given you any problems.
Clozapine is not suitable for elderly people with psychosis that is related to dementia.
Are there any restrictions on the type of food I can take?
Avoid alcohol. Alcohol will worsen the dizziness and drowsiness caused by Clozapine.
Why do I need this medicine?
Clozapine is used to treat schizophrenia. It helps to relieve symptoms common in schizophrenia, such as distorted thinking and emotional instability. It also helps to reduce the risk of suicidal behaviour in schizophrenia.
Clozapine is also used to treat distorted thinking and emotional instability in Parkinson's disease.
What side effects could I experience?
Clozapine may make you drowsy or dizzy. Do not drive or take part in any activity in which you need to be alert. Dizziness may be worse when you get up from a sitting or lying down position, especially if you are taking Clozapine for the first time or if your dose is still being adjusted. This is normal and should disappear gradually as you get used to the medicine. It will help if you get up slowly from a sitting or lying down position.
Clozapine may cause fits or seizures in some people. Do not take part in any activities where a sudden loss of consciousness may be dangerous. Avoid activities such as driving, operating machinery, swimming or climbing.
Clozapine may also cause constipation. If you develop severe constipation, alert your doctor quickly.
Other common side effects with Clozapine include headache, nausea, drooling, difficulty sleeping, tremor, eyesight problems and weight gain. Inform your doctor if these side effects become severe or refuse to go away.
Other side effects are less common but may need immediate medical help. Alert your doctor immediately if you experience any of these symptoms:
- rapid or irregular heartbeat
- chest pain
- any signs of an impending heart attack
- difficulty breathing or wheezing
- severe tiredness or weakness
- fever with persistent sore throat or mouth ulcers, or other signs of infection
- uncontrolled muscle movements of your body, face or tongue, such as lip smacking or worm-like movements of the tongue
- muscle stiffness or spasm
- excessive sweating
- rapid rise in your body temperature or an inability to cool down on a hot day
- excessive or persistent drowsiness or dizziness
- yellowing of the eyes or skin
- swelling, pain or redness in the lower leg
How should I store this medicine?
Store in a cool, dry place away from the reach of children.
Medicines must not be used past the expiry date.
Can I take/use this with other medicines?
Alert your doctor if you are taking any medicines that may cause bone marrow suppression or a decreased white blood cell count. Some examples of such medicines are cancer medication, antibiotics like chloramphenicol, cotrimoxazole and sulfonamides, certain painkillers such as phenylbutazone, and an arthritis medication called penicillamine. There are many other medicines that may lower your white blood cell count or cause bone marrow suppression. Always ask your doctor or pharmacist if you are not sure.
Alert your doctor if you are taking any of these medicines:
- sleeping pills such as diazepam, alprazolam or similar
- diabetes medicines
- certain heart medicines such as digoxin
- blood-thinners such as warfarin
- mood medicines such as citalopram or risperidone
- medicines that can cause drowsiness such as opioid painkillers (e.g. morphine), antihistamines
- high blood pressure medicines
- metoclopramide (medicine used to treat nausea or vomiting)
- antibiotics such as norfloxacin or ofloxacin
- omeprazole (gastric medicine)
- epilepsy (fits) medicines such as valproic acid, phenytoin or carbamazepine
- certain mood medicines such as lithium
- nicotine-containing products such as cigarettes and anti-smoking patches
Always alert your doctor or pharmacist if you are taking any other medicines, including herbal tonics, supplements and medicines that you buy without a prescription.